Can Spravato Help When Antidepressants Do Not Work? Depression does not always respond to traditional medications. For eligible adults with treatment-resistant depression, Spravato® (esketamine) may provide another treatment option. It is an FDA-approved nasal spray that works through the brain's NMDA receptor pathway. At Dr. Nudman Psychiatrist, treatment starts with a detailed psychiatric evaluation to understand symptoms, previous medications, medical history, and personal needs. Spravato is administered under professional supervision, with patients monitored after each session. A personalized assessment helps determine whether this treatment may be suitable for an individual's mental health needs. Visit us: https://selficlub.com/drnudman